|
| Name | Type | Slot | Bonuses | Effects | Requirements |
| Sacred Oil | | | | | |
| Salmon | Food | | | +9 Hit Points | |
| Salve Amulet | Armor | Jewelry | Crush Defense +3, Prayer +3, Slash Defense +3, Stab Defense +3 | +15% Strength and Accuracy Bonus vs. Undead | |
| Salve Shard | | | | | |
| Sample Bottle | | | | | |
| Sandstone | | | | | |
| Santa Hat | Armor | Head | | | |
| Sapphire Amulet | | | | | |
| Sapphire Bolt Tip | Weapon | Ammo | | | |
| Sapphire Lantern | | | | | |
| Saradomin Cape | Armor | Back | Magic Attack +10, Magic Defense +10 | | |
| Saradomin Godsword | Weapon | | Strength +132, Prayer +8. +132 slash, +80 crush | Special attack, highest damage 70
Special heals 50% of damage dealt to health and 25% of damage dealt to prayer. | 75 attack |
| Saradomin Kiteshield | Armor | Secondary | Crush Defense +46, Magic Attack -8, Magic Defense -1, Ranged Attack -2, Ranged Defense +46, Slash Defense +48, Stab Defense +44 | | Defense: 40 |
| Saradomin Large Helm | Armor | Head | Crush Defense +27, Magic Attack -6, Magic Defense -1, Ranged Attack -2, Ranged Defense +30, Slash Defense +32, Stab Defense +30 | | Defense: 40 |
| Saradomin Platebody | Armor | Body | Crush Defense +72, Magic Defense -6, Ranged Defense +80, Slash Defense +80, Stab Defense +82 | | Defense: 40 |
| Saradomin Platelegs | Armor | Legs | Crush Defense +47, Magic Defense -4, Ranged Defense +49, Slash Defense +29, Stab Defense +51 | | Defense: 40 |
| Saradomin Staff | Weapon | Primary | Crush Attack +6, Magic Attack +6, Slash Attack -1, Stab Attack -1 | | Magic: 60 |
| Sardine | | | | | |
| Saw | | | | | |
| Scorpion Cage | | | | | |
| Scrap Paper | | | | | |
| A Scruffy Note | | | | | |
| Scythe | Weapon | Primary | Crush Attack +3, Crush Defense +1, Slash Attack +8, Slash Defense +3, Stab Attack +3, Strength +10 | | |
| Seal of Passage | | | | | |
| Seasoned Sardine | Food | | | | |
| Seaweed | | | | | |
| Seaweed Sandwich | | | | | |
| Secateurs | | | | | |
| Security Book | | | | | |
| Seed Dibber | | | | | |
| Seercull Bow | Weapon | | Ranged Attack +69 | Lowers Targets Magic | Ranged: 50 |
| Selected Iron | | | | | |
| Serum 208 | | | | | |
| Serum 208(p) | | | | | |
| Sextant | | | | | |
| Shade Robe (Bottom) | Armor | Legs | Prayer +4 | | |
| Shade Robe (Top) | Armor | Body | Prayer +4 | | |
| Shark | Food | | | | |
| Shears | | | | | |
| Shed Key | | | | | |
| Sheep Bones | | | | | |
| Shield Left Half | | | | | |
| Shield Right Half | | | | | |
| Shiny Key | | | | | |
| Shorts | Armor | Legs | | | |
| Shovel | | | | | |
| Shrimp | Food | | | Heal (4 hit points) | |
| Silk | | | | | |
| Silver Bar | | | | | |
| Silver Dust | | | | | |
| Silver Ore | | | | | |
| Silver Sickle Mold | | | | | |
| Silverlight | Weapon | Primary | Crush Attack -2, Crush Defense +2, Magic Defense +1, Slash Attack +14, Slash Defense +3, Stab Attack +9, Strength +12 | Weaken Demon | |
| Sito Foil | | | | | |
| Skavid Map | | | | | |
| Skirt | Armor | Legs | | | |
| Slave Robe | Armor | Body | | | |
| Slave Shirt | Armor | Body | | | |
| Slayer Gloves | Armor | Hands | Crush Defense +3, Slash Defense +5, Stab Defense +4 | | |
| Slayer's Respite | Drink | | | Temporarily Raiase Slayer Level (+2) | |
| Slender Blade | Weapon | Primary | | | |
| Slice of Cake | Food | | | Heal (4 hit points) | |
| Slop of Compromise | | | | | |
| Small Cog | | | | | |
| Small Fishing Net | | | | | |
| A Small Key | | | | | |
| Small Pouch | | | | | |
| Smouldering Pot | | | | | |
| Snake Corpse | | | | | |
| Snake Weed | | | | | |
| Snape Grass | | | | | |
| Snowdrop Seed | | | | | |
| Soaked Kindling | | | | | |
| Soda Ash | | | | | |
| Sodium Chloride | | | | | |
| Soft Clay | | | | | |
| Soggy Bread | | | | | |
| Soul Rune | | | | | |
| Spade | | | | | |
| A Special Tiara | | | | | |
| Specimen Brush | | | | | |
| Specimen Brush | | | | | |
| Specimen Jar | | | | | |
| Specimen Jar | | | | | |
| Sphinx's Token | | | | | |
| Spiced Maggots | | | | | |
| Spiked Boots | Armor | Feet | | | |
| Spinach Roll | Food | | | Heal (2 hit points) | |
| Spinning Plate | | | | | |
| Spiny Helmet | Armor | Head | | | |
| Spirit Seed | | | | | |
| Square Sandwich | Food | | | Heal (6 hit points) | |
| Staff | Weapon | Primary | Crush Attack +7, Crush Defense +1, Magic Attack +4, Magic Defense +4, Slash Attack -1, Slash Defense +3, Stab Defense +2 | Heal (6 hit points) | |
| Stake | | | | | |
| Stamped Certificate of Recommendation | | | | | |
| Star Amulet | | | | | |
| Star Bauble | | | | | |
| Starflower | | | | | |
| Statuette | | | | | |
| Steel 2H Sword | Weapon | Primary | Crush Attack +16, Magic Attack -4, Ranged Defense -1, Slash Attack +21, Stab Attack -4, Strength +22 | | |
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