| Name | Class | Type | XP Level | Location |
| Eadburg | Monster | Human | 4 | Burthorpe |
| Eadgar | NPC | Trollheim | ||
| Eagle-Eye Schultz | Quest NPC | Pirate's Cove | ||
| Earth Elemental | Monster | Elemental | 35 | Seer Village |
| Earth Warrior | Monster | Elemental | 51 | Edgeville Dungeon |
| Earth Wizard | Monster | Human | 13 | |
| Easter Bunny | NPC | Falador | ||
| Eblis | Quest NPC | Kharidian Desert | ||
| Echned Zekin | Monster | 187 | ||
| Edmond | Quest NPC | Vendor | Ardougne | |
| Effigy | Quest NPC | Ardougne | ||
| Elder Guard | Quest NPC | Guard | Marim | |
| Eldgrim | NPC | Guard | Rellekka | |
| Elena | Quest NPC | Guard | Ardougne | |
| Elf Tracker | Quest NPC | Tirannwn | ||
| Elf Warrior | NPC | Guard | Tirannwn | |
| Elf Warrior | Monster | Elf | 108 | Tirannwn |
| Elissa | Quest NPC | Varrock | ||
| Elizabeth | Quest NPC | Seer Village | ||
| Elkoy | NPC | |||
| Ellamaria | NPC | Varrock | ||
| Ellena | NPC | Catherby | ||
| Ellis | NPC | Varrock | ||
| Ellis | NPC | Al Kharid | ||
| Elstan | Quest NPC | Falador | ||
| Eluned | Quest NPC | Isafdar | ||
| Elvarg | Monster | Dragon | 83 | Karamja Dungeon |
| Elven City Guard | NPC | |||
| Emerald Benedict | NPC | Burthorpe | ||
| Emily | NPC | Falador | ||
| Emily | NPC | Falador | ||
| Enakhra | NPC | |||
| Enclave Guard | Monster | Ogre | 83 | Gu'Tanoth |
| Ent | ||||
| Entrana Fire Bird | Monster | Animal | 2 | |
| Eohric | Quest NPC | Burthorpe | ||
| Eoin | NPC | Lettya | ||
| Erin | NPC | Silver Merchant | Ardougne | |
| Ermin | NPC | |||
| Ernest | Quest NPC | Draynor | ||
| Escaping Slave | NPC | |||
| Essyllt | Quest NPC | Tirannwn | ||
| Estate Agent | NPC | Ardougne, Falador, Seer Village, Varrock | ||
| Ethereal Expert | Quest NPC | Dreamland | ||
| Ethereal Fluke | Quest NPC | Dreamland | ||
| Ethereal Guide | Quest NPC | Dreamland | ||
| Ethereal Lady | Quest NPC | Dreamland | ||
| Ethereal Man | Quest NPC | Dreamland | ||
| Ethereal Mimic | Quest NPC | Dreamland | ||
| Ethereal Numerator | Quest NPC | Dreamland | ||
| Ethereal Perceptive | Quest NPC | Dreamland | ||
| Eudav | NPC | Lettya | ||
| Evil Bob | NPC | |||
| Evil Chicken | Monster | Animal | ||
| Evil Dave | Quest NPC | Edgeville | ||
| Examiner | Quest Monster | |||
| example | Location this mob can be found in. Ex: Varrock | |||
| Experiment | Monster | Animal | 25 | |
| Ezekial Lovecraft | Quest NPC | |||
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